Men and women can totally co-exist with one another just as long as it's clear that when women say certain things they may mean the total opposite of what they're feeling. It's really up to guys to be smart and figure it out. The sooner you read between the proverbial lines, the happier you'll both be.
No matter how many times she says it, something you did has totally pissed her off. So you better put on your thinking cap or retrace your steps and figure out what you did wrong so you can apologize right away! Grovel if necessary.